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Epigenomics
Epigenomics

Epigenomics is the study of the complete set of chemical epigenetic modifications on the genetic material of a cell, known as the epigenome. Epigenetic modifications are heritable, reversible modifications on a cell’s DNA or histones that affect gene expression without altering the DNA sequence.

The main epigenetic mechanisms are DNA methylation, histone modification and non-coding RNA-associated gene silencing. The Oxford Nanopore sequencing technology will be applied for our epigenomics work, seen its clear advantages as for instance the simple and rapid PCR-free library preparation that prevents loss of epigenetic modifications and thus the ability to perform direct DNA sequencing. Different types of double stranded DNA can be measured as for example genomic DNA (gDNA), complement DNA (cDNA) or amplicons.

DNA modifications

DNA methylation can be obtained by direct whole genome sequencing with the Oxford Nanopore technology.

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RNA modifications

A role for DNA modification in gene regulation is well established, but much less is known about how RNA modifications can affect RNA fate and influences the way translation is affected.

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Applications
Applications

The ONT-based genomics experiments can be applied for a broad range of biological research applications. These include large scale human genomics, cancer research, microbiology, plant science and environmental research where the length of the sequenced reads and the direct measurement of possibly modified bases has its clear advantage.

  • Complete understanding of genetic variation. Sequence whole genomes or targeted regions. Fully characterize structural variation (SV), repetitive regions, single nucleotide variation (SNV) haplotype phasing and epigenetic modifications.
  • Nanopore DNA sequencing delivers comprehensive analysis of clinical research samples, providing rapid insight into infectious disease, microbiome analysis, cancer research, immunology, reproductive health and many other areas of biomedical research. Comprehensive and rapid analysis of DNA mutations, rearrangements, deletions is enabled in for instance cancer research.
  • Nanopore sequencing enables comprehensive, real-time microbiome analysis. Rapidly identify and characterize microbes from environmental and microbiota samples.
  • Long sequencing reads allow complete characterization of repeat regions, structural variation and transposons for plants.
  • Nanopore sequencing holds promise to become the technology of choice to perform forensic profiling.

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