Quality control of cell lines

Quality control of cell lines

Precision Sequencing for Cell Line Authentication

Ensuring the genomic integrity of engineered cell lines is a fundamental step in the development of biologics. OHMX.bio specializes in applying long-read sequencing to provide the most comprehensive and accurate picture of cell line quality. Our approach allows for the full characterization of engineered modifications, detection of unintended edits, and precise mapping of insertions or transgenes.
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Why long-read sequencing?

Traditional short-read methods often miss large structural variations or cannot resolve full insertion sequences. By contrast, OHMX.bio uses Oxford Nanopore long-read sequencing to directly read entire constructs and flanking genomic regions. This enables:

  • Detection of full-length insertions and their exact genomic locations
  • Identification of rearrangements, duplications, or deletions
  • Verification of on-target vs off-target integration
This level of detail is crucial for confirming the identity, purity, and stability of production cell lines used in biologics manufacturing.
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Comprehensive quality insights

OHMX.bio’s workflows include dedicated protocols for sample preparation and sequencing of various cell types, including CHO, HEK293, and other mammalian or even plant-derived systems.
Our platform provides end-to-end insight into:

Confirmation of engineered regions

Detection of residual plasmid sequences

Monitoring of genetic drift over time

These data points help define and track CQAs relevant for both research and regulatory submission.
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Bioinformatics-driven confidence

All sequencing outputs are processed through OHMX.bio’s validated bioinformatics pipelines, ensuring accurate variant calling, insertion mapping, and structural analysis. Our team delivers publication-ready reports and works with clients to interpret complex data in the context of quality control. This makes our service ideal for both early development and late-phase validation of engineered cell lines.
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Expertise that scales with your needs

From initial cell line engineering to preclinical and GMP validation, OHMX.bio brings years of sequencing and analytical experience to support your QC strategy. Let us help ensure the genetic fidelity of your cell lines, streamline your regulatory path, and strengthen your confidence in every engineered construct.

Let’s get in touch!

Are you curious about how we can work on your -omics challenges together? Fill out the form below!
Our experts will reply within 2 working days to freely discuss your omics project.

Our publications using cell line solutions

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