mRNA solutions

mRNA solutions

Messenger RNA (mRNA) is at the forefront of therapeutic innovation, offering a versatile platform for vaccines, protein replacement therapies, and immunotherapies. However, its inherent instability and complexity demand rigorous quality control throughout development and production.
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At OHMX.bio, we offer specialized QC services for mRNA-based products, leveraging Nanopore long-read sequencing to deliver full-length transcript analysis with single-molecule resolution. This allows for accurate characterization of mRNA integrity, sequence fidelity, 5’ and 3’ end structures, poly(A) tail length, and potential contaminants—all in a single assay. Compared to traditional methods, this approach is not only more accurate and streamlined, but also more economical.
Our mRNA QC workflow supports both research-grade and GMP-compliant* environments, enabling fast and flexible analysis across development stages. Whether you’re optimizing an in vitro transcription protocol or preparing material for clinical-grade production, OHMX.bio provides the data and insight to move forward with confidence.

Sample prep Library prep QC

Read lengths of >20kb

Bioinformatics analysis'

Full report

sequencing quality & metrics calculated mRNA cQAs

Direct RNA protocol

Direct cDNA Protocol

mRNA QC workflow
mRNA QC workflow
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*offered through our GMP accredited sister-entity Anabiotec
Through our close collaboration with our sister company Anabiotec, a Contract Manufacturing and Control (CMC) service provider with over 20 years of experience in GMP-compliant analysis, we offer access to a broad spectrum of traditional quality control methods alongside our advanced sequencing-based workflows. This unique combination allows us not only to deliver state-of-the-art mRNA analysis, but also to directly compare results across platforms, bridging innovation with regulatory-proven methodologies to support our clients at every stage of development.
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Our experts will reply within 2 working days to freely discuss your omics project.

Frequently asked questions about our mRNA solutions

mRNA therapeutics are highly sensitive to degradation, structural variation, and impurities. Rigorous quality control is essential to confirm sequence integrity, correct 5′ and 3′ end structures, poly(A) tail length, and absence of contaminants. Without comprehensive analysis, therapeutic performance and safety may be compromised.
OHMX.bio uses Nanopore long-read sequencing to perform full-length transcript analysis at single-molecule resolution. This enables simultaneous assessment of mRNA integrity, sequence fidelity, poly(A) tail length, end structures, and contaminant detection in a single assay. Compared to traditional QC approaches, this method provides more comprehensive structural insight.
Yes. The workflow supports both research-grade and GMP-compliant environments. Through collaboration with Anabiotec, a GMP-accredited CMC service provider, traditional QC methods can be combined with sequencing-based analysis to meet regulatory requirements across development stages.
Combining long-read sequencing with established QC methods allows cross-validation of results. This integration bridges innovation with regulatory-proven methodologies, improving confidence in data quality while accelerating development timelines.

Our publications using mRNA solutions

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Sample prep Library prep QC

Read lengths of >20kb

Bioinformatics analysis'

Full report

sequencing quality & metrics calculated mRNA cQAs

Direct RNA protocol

Direct cDNA protocol

mRNA QC workflow
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