Epigenetic Sequencing

Epigenetic sequencing

Unlock new insights into gene regulation with OHMX.bio’s advanced epigenetic sequencing services. By analyzing DNA and RNA modifications, OHMX.bio provides a comprehensive understanding of how gene expression is controlled beyond genetic sequences.
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What is epigenetic sequencing?

Epigenetic sequencing investigates chemical modifications to DNA and RNA that influence gene activity without altering the underlying genetic code. These modifications play a crucial role in development, disease mechanisms, and therapeutic responses. OHMX.bio’s state-of-the-art sequencing solutions allow for high-resolution detection of epigenetic marks, helping researchers explore gene regulation in unprecedented detail.
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Oxford Nanopore long-read sequencing for epigenetics

OHMX.bio leverages Oxford Nanopore’s long-read sequencing technology to directly detect base modifications, such as DNA methylation and RNA modifications, without the need for chemical conversion. This approach preserves the native structure of nucleic acids, providing:

Direct Detection of Methylation and Other Modifications

at single-nucleotide resolution.

Directly Detect Base Modifications On DNA and RNA During Sequencing

to analyze transcript modifications.

Long-read capabilities

to resolve complex regions and repetitive elements.

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Bisulfite sequencing for DNA methylation

OHMX.bio also offers bisulfite sequencing, a widely used method for detecting 5-methylcytosine (5mC) modifications in DNA. This method relies on chemical conversion to distinguish methylated from unmethylated cytosines, making it an effective tool for studying methylation patterns at high coverage. Bisulfite converted DNA is typically sequenced using short-read sequencing due to the fragmentation of the DNA during the conversion.
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Choosing the right approach: Oxford Nanopore vs. Bisulfite sequencing

Selecting the best method for epigenetic analysis depends on specific research needs.

Oxford Nanopore Sequencing (ONT)

Enables direct detection of multiple base modifications, such as 5mC and 6mA, without chemical conversion. ONT is particularly valuable for detecting modifications in both DNA and RNA, making it a versatile tool for epigenetic studies. Its long-read capabilities allow for better resolution of complex genomic regions, repetitive sequences, and phased methylation patterns. However, ONT has a slightly higher error rate compared to short-read sequencing methods, which can be mitigated with optimized data processing and coverage.

Bisulfite Sequencing

Offers high accuracy in detecting 5mC modifications but requires chemical treatment, which converts unmethylated cytosines to uracil while leaving methylated cytosines unchanged. This process can introduce DNA degradation and sequencing biases, potentially affecting data quality. Bisulfite sequencing provides high-resolution methylation mapping at a lower per-base error rate than ONT but does not detect RNA modifications or other epigenetic marks.

Oxford Nanopore sequencing is ideal for researchers looking for a comprehensive view of epigenetic modifications across long genomic regions, while bisulfite sequencing remains a gold standard for high-accuracy DNA methylation analysis.
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Applications of epigenetic sequencing

OHMX.bio’s epigenetic sequencing solutions are ideal for:

Cancer Epigenetics

Identify methylation changes linked to tumor progression.

Neuroscience & Aging

Study the role of epigenetic modifications in neurodegeneration and aging-related diseases.

Developmental Biology

Explore how epigenetic mechanisms shape gene expression during development.

Drug Response & Biomarker Discovery

Investigate epigenetic markers for personalized medicine.

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Let’s get in touch!

Are you curious about how we can work on your -omics challenges together? Fill out the form below!
Our experts will reply within 2 working days to freely discuss your omics project.

Our publications using our epigenetic profiling services

  1. Iyer, Shruti V., Sara Goodwin, and William Richard McCombie. “Leveraging the power of long reads for targeted sequencing.” Genome research 34.11 (2024): 1701-1718.
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