Clinical Solutions

Clinical sequencing solutions

OHMX.bio’s clinical sequencing solutions are designed to meet the rigorous demands of clinical research, diagnostics, and therapeutic development. By adhering to the highest quality and regulatory standards, we deliver reliable, actionable insights to support breakthroughs in a wide range of applications, from cell & gene therapy to oncology, immunology, and infectious diseases.
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Genomics

Transcriptomics

Immune monitoring

Mutation analysis

Microbiome

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Genomics

Genomics profiling enables researchers to identify genetic variations, structural changes, and mutations that underpin disease mechanisms. Whether applied to oncology or rare genetic disorders, these insights provide a foundation for targeted therapies. The same profiling techniques can be used to validate genetic edits in cell and gene therapy applications, ensuring their safety and efficacy.
OHMX.bio offers several DNA sequencing solutions that can be tailored to your needs and samples. Use the power of long-read strands to cover large genomic regions, or make use of our Element Biosciences AVITI sequencer, with unparalleled read-accuracy (>90% Q40) for variant analysis. OHMX.bio can offer commercially available library enrichment kits, such as the Illumina TruSight Oncology 500 (TSO500; Qiagen), FoundationOne CDx (Foundation medicine) and Oncomine Panels (Thermo Fisher Scientific), but can also design and process custom library kits.
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Genomics

Genomics profiling enables researchers to identify genetic variations, structural changes, and mutations that underpin disease mechanisms. Whether applied to oncology or rare genetic disorders, these insights provide a foundation for targeted therapies. The same profiling techniques can be used to validate genetic edits in cell and gene therapy applications, ensuring their safety and efficacy.
OHMX.bio offers several DNA sequencing solutions that can be tailored to your needs and samples. Use the power of long-read strands to cover large genomic regions, or make use of our Element Biosciences AVITI sequencer, with unparalleled read-accuracy (>90% Q40) for variant analysis.
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Transcriptomics

RNA sequencing is a powerful tool to understand gene expression patterns and how they shift in response to disease or treatment. This approach is critical to get insights into pathways and mechanisms of action. RNA sequencing also supports translational profiling (ribosomal profiling), bridging the gap between preclinical studies and clinical applications by uncovering key biological pathways that drive therapeutic effects.
OHMX.bio can handle high-throughput RNA sequencing under GCLP conditions, with an accurate and short TAT to ensure your trials run efficiently. RNA sequencing is an ideal starting point for discovering biomarkers, which OHMX.bio can help translate downstream to more scalable solutions, such as qPCR.
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Immune monitoring

Characterizing immune system dynamics is central to advancing therapies for autoimmune conditions, cancer, and beyond. Clinical sequencing can profile T-cell and Bcell repertoires, revealing diversity and clonal expansion that indicate immune responses. In oncology, sequencing provides detailed insights into the tumor microenvironment, uncovering how cancer cells interact with the immune system and identifying biomarkers that predict therapeutic outcomes.
OHMX.bio is an expert in HLA typing and microbiome studies. For an ever more detailed insight into T- and B-cells, OHMX.bio can also perform single cell BCR and TCR sequencing.
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Mutation analysis

The ability to detect and analyze mutations is fundamental to many therapeutic applications. In oncology, sequencing can identify driver mutations, actionable targets, and resistance mechanisms. These same capabilities extend to cell and gene therapies, where mutation analysis ensures the integrity of therapeutic constructs. Sequencing also enables longitudinal monitoring of patients undergoing treatment, capturing molecular changes that inform adjustments to therapeutic strategies.
OHMX.bio can deploy its deep variant analysis bioinformatics tool to detect rare mutations in samples. The combination of the Element Biosciences AVITI sequencer, which has unparalleled read-accuracy (>90% Q40), with the Deep Variant pipeline is a winning combination.
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Why sequencing-based biomarkers are reshaping precision medicine

Microbiome

The microbiome plays a critical role in immune regulation, metabolism, and disease susceptibility. Shifts in microbial composition and function have been associated with conditions ranging from inflammatory bowel disease and metabolic syndrome to neurodegenerative disorders and cancer. Profiling the microbiome in a clinical context opens the door to biomarker discovery, patient stratification, and the evaluation of microbiome-modulating therapies.
OHMX.bio offers a comprehensive microbiome analysis platform, leveraging Oxford Nanopore long-read sequencing for full-length 16S rRNA and ITS amplicon sequencing, enabling accurate species-level taxonomic resolution. For deeper functional insights, OHMX.bio can deploy shotgun metagenomics and metatranscriptomics to uncover the metabolic potential and active gene expression of entire microbial communities. Our optimised workflows support high-throughput processing of large sample cohorts, making OHMX.bio a reliable partner for multi-centre studies and longitudinal clinical trials.
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Integrated bioinformatics

OHMX.bio supports clinical sequencing with robust bioinformatics pipelines tailored for large-scale data processing and interpretation. Our expert team ensures accurate and reproducible results, delivering comprehensive reports that transform complex data into actionable insights. By integrating data from multiple -omics platforms, we offer a holistic view of biological systems, enhancing the impact of clinical and translational research.

Quality and compliance

Our commitment to excellence is reflected in our adherence to globally recognized quality standards

ISO 9001 Certification

Ensuring consistency and quality in all processes.

ISO 27001 Certification

Protecting the security of your data at every step.

GCLP Standards

Providing regulatory compliance for clinical-grade sequencing.

GMP-Accredited Laboratories

Operating in facilities that meet the highest standards for manufacturing and clinical research.

These certifications and practices underscore our ability to support regulated environments and deliver results you can trust.

Let’s get in touch!

Are you curious about how we can work on your -omics challenges together? Fill out the form below!
Our experts will reply within 2 working days to freely discuss your omics project.
Genomics
Immune repertoire and microenvironment analysis
Transcriptomics
Mutation analysis and therapeutic monitoring
Other solutions
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