Quality control of viral vectors

Quality control of viral vectors

Ensuring the Integrity of Viral Vectors through Sequencing

Viral vectors are critical tools in gene therapy, vaccine development, and cell engineering, but their complexity demands robust quality control to ensure safety and functionality. At OHMX.bio, we specialize in using Oxford Nanopore long-read sequencing to deliver the most accurate and comprehensive assessment of viral vector preparations. This technology enables full-length genome sequencing, structural variant detection, and epigenetic profiling in a single run, providing an unparalleled view into the quality and consistency of your viral vector constructs.
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Applications for regulatory and developmental use

With increasing regulatory scrutiny, it is essential to demonstrate the integrity of viral vector genomes and the absence of contaminants or unexpected rearrangements. OHMX.bio’s sequencing workflows are optimized for:

  • Full-genome sequencing of AAVs, lentiviruses, and other vectors
  • Detection of truncations, rearrangements, and inversions
  • Identification of contaminants, such as host cell or plasmid DNA
  • Quantitative assessment of vector genome heterogeneity
These insights help monitor and validate Critical Quality Attributes (CQAs) that are central to the safety and efficacy of gene therapy vectors.
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Bioinformatics expertise for viral vector QC

Beyond sequencing, OHMX.bio provides advanced bioinformatics pipelines tailored for viral vector quality control. Our analysis tools offer detailed mapping of vector genomes, structural integrity evaluation, and quantification of minor variants. By integrating scientific expertise with computational precision, we ensure your data meet both R&D and regulatory requirements.

Why OHMX.bio?

OHMX.bio combines deep scientific expertise with cutting-edge technology to deliver actionable insights in viral vector quality control. Our long-read sequencing approach minimizes time-to-result while offering full transparency into CQAs. Whether for preclinical development or regulatory submission, OHMX.bio ensures your viral vectors meet the highest standards of quality, accuracy, and compliance.
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Let’s get in touch!

Are you curious about how we can work on your -omics challenges together? Fill out the form below!
Our experts will reply within 2 working days to freely discuss your omics project.

Our publications using viral vector solutions

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