TCR and BCR sequencing

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Instruments

Available setups

Sample types

Bioinformatics expertise

What is TCR and BCR sequencing?

T-cell receptor (TCR) and B-cell receptor (BCR) sequencing provide detailed insights into the adaptive immune repertoire by profiling the diversity and clonality of T and B lymphocytes. These technologies are critical for studying immune responses in infectious disease, cancer immunotherapy, autoimmunity, and vaccine development.
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Instruments

TCR and BCR sequencing is conducted using the AVITI platform in-house for bulk sequencing. For single-cell TCR and BCR sequencing, OHMX.bio utilizes the PARSE TCR and BCR kits.

Available setups

Bulk TCR/BCR Sequencing
Involves targeted amplification of TCR or BCR chains followed by sequencing on the AVITI system. Suitable for high-throughput immune repertoire profiling.

Single-Cell TCR/BCR Sequencing
Uses PARSE fixation-based chemistry to simultaneously capture transcriptome and receptor data at the single-cell level, enabling deep insights into clonal dynamics and cellular context.

Sample types

Applicable to peripheral blood mononuclear cells (PBMCs), tumor-infiltrating lymphocytes (TILs), lymph node samples, and other dissociated immune tissues. For sample handling details, see sample requirements page.

Advantages

  • High-resolution immune repertoire profiling
  • Bulk and single-cell formats available
  • Fixation-based approach allows long-term sample storage and centralized processing
  • Enables integration with transcriptome data in single-cell applications

Common Applications

  • Monitoring clonal expansion during immunotherapy
  • Investigating autoimmune disease mechanisms
  • Vaccine response studies
  • Immune cell characterization in tumor microenvironments

Integrated bioinformatics expertise

The bioinformatics team at OHMX.bio provides tailored analysis pipelines for clonotype calling, diversity metrics, and longitudinal tracking. Visualizations and summary reports support in-depth understanding and decision-making in both discovery and translational research contexts.
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Partner with OHMX.bio

Whether you are conducting fundamental research, developing novel therapeutics, or advancing clinical diagnostics, OHMX.bio’s lab- and bio-IT solutions are here to support your goals. Our commitment to innovation, quality, and client success makes us the ideal partner for generating advanced biological insights.
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Let’s get in touch!

Are you curious about how we can work on your -omics challenges together? Fill out the form below!
Our experts will reply within 2 working days to freely discuss your omics project.

Our publications using TCR and BCR sequencing solutions

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