Quality control of plasmids

Quality control of plasmids

Complete Plasmid Characterization Using Long-Read Sequencing

Plasmids are the backbone of many gene therapy, vaccine, and biologics production workflows. Whether used as delivery tools or templates for mRNA synthesis, their sequence integrity is critical for downstream success. OHMX.bio leverages Oxford Nanopore long-read sequencing to provide full-length, high-resolution plasmid analysis—ensuring that every backbone, insert, and regulatory element is correct, complete, and free of unintended changes.
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Accurate assessment of plasmid quality attributes

Our workflows are specifically designed to verify Critical Quality Attributes (CQAs) relevant to plasmid constructs, including:

  • Confirmation of complete and correct plasmid sequences
  • Detection of insertions, deletions, or point mutations
  • Identification of structural variants or recombination events
  • Screening for unwanted backbone rearrangements or contaminants
By using long-read sequencing, we can capture the entire plasmid structure in a single read, avoiding the limitations of short-read fragmentation and PCR-based bias.
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Tailored bioinformatics for plasmid QC

OHMX.bio supports every sequencing project with dedicated bioinformatics pipelines. For plasmid quality control, this includes full plasmid annotation, alignment to reference sequences, and variant reporting with high confidence. Our tools help you document and understand all relevant quality attributes, facilitating both internal QC and regulatory submissions.

Trusted expertise in plasmid validation

With years of experience in supporting biologics development, OHMX.bio has built trusted workflows for accurate plasmid validation. From preclinical research to clinical-grade production support, our scientific and computational capabilities ensure that your plasmid-based products meet rigorous quality standards, delivered with speed, precision, and reliability.
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Let’s get in touch!

Are you curious about how we can work on your -omics challenges together? Fill out the form below!
Our experts will reply within 2 working days to freely discuss your omics project.

Our publications using plasmid solutions

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