Genomics

Genomics involves the sequencing and analysis of genomes through use of high throughput DNA sequencing techniques and bioinformatics to assemble and analyze the function and structure of entire genomes.

We offer complete genomics testing service pipelines for a broad range of biological and clinical sample types going from human to plants, animals, bacteria and viruses. The Oxford Nanopore Technology will be applied for our genomics work, seen its clear advantages as for instance the sequencing of (ultra-) long reads up to 2 Megabases, the ability to perform direct DNA sequencing and the simple and rapid library preparation. Different types of double stranded DNA can be sequenced as for example genomic DNA (gDNA), complement DNA (cDNA) or amplicons.

Based on your demands, we can also choose for the classic Illumina based sequencing strategies.

Genomic DNA sequencing

A comprehensive method for analyzing entire genomes.

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Exome
sequencing

A focused strategy on the protein-coding genes of the genome.

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Targeted
(Re)sequencing

Sequence only the regions of your interest.

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Applications

The Oxford Nanopore Technology-based genomics experiments can be applied for a broad range of biological research applications. These include large scale human genomics, cancer research, microbiology, plant science and environmental research where the length of the sequenced reads and the direct measurement of possibly modified bases has its clear advantage.

Complete understanding of genetic variation. Sequence whole genomes or targeted regions. Fully characterize structural variation (SV), repetitive regions, single nucleotide variation (SNV) haplotype phasing and epigenetic modifications.
Nanopore DNA sequencing delivers comprehensive analysis of clinical research samples, providing rapid insight into infectious disease, microbiome analysis, cancer research, immunology, reproductive health and many other areas of biomedical research. Comprehensive and rapid analysis of DNA mutations, rearrangements, deletions is enabled in for instance cancer research.
Nanopore sequencing enables comprehensive, real-time microbiome analysis. Rapidly identify and characterize microbes from environmental and microbiota samples.
Long sequencing reads allow complete characterization of repeat regions, structural variation and transposons for plants.
Nanopore sequencing holds promise to become the technology of choice to perform forensic profiling.

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